Pirfenidone
Description
Generic Name: pirfenidone
Drug Class: pyridone
Indications
Esbriet is an oral prescription drug used to treat a lung disease called idiopathic pulmonary fibrosis (IPF). This is a chronic, progressive disease that causes scar tissue to build up in the lungs, making them unable to transport oxygen into circulation.
Esbriet Dosage Forms
This is available in 200 mg tablet which is not equivalent to the one available in the US, Esbriet 267 mg. For the difference in strength, your doctor can be contacted to get approval on dispensing the 200 mg strength.
Esbriet Mechanism of Action
The exact action of this oral pyridone is unknown. However, it is thought to reduce growth factor signaling. It acts on multiple pathways that are known to be involved in lung tissue scarring. As a result, it can slow the progression of IPF.
How to Take Esbriet
Before using Esbriet, it is necessary to read the information leaflet or medication guide given by a healthcare professional. You must avoid taking Esbriet or any medication unless you have talked to your doctor and understood the uses and directions.
Esbriet is only meant to be taken by mouth. This is usually prescribed three times a day. You must take it with a meal to reduce dizziness or nausea. Swallow it entirely and drink fluids right after.
Schedule when you take your medication so you don’t forget to take it. Do not increase or decrease your Esbriet dose. Your physician may initiate with a low dose and gradually increase your dose as you go on with the treatment. You should also not take this oral drug more frequently than advised.
Esbriet Side Effects
Mild & Common Side Effects:
-Dizziness
-Nausea
-Vomiting
-Diarrhea
-Heartburn
-Loss of appetite
-Weight loss
-Lack of energy
-Tiredness
-Changes in taste
Severe Side Effects:
-Persistent nausea and vomiting
-Severe abdominal pain
-Dark urine
-Yellowing of the eyes and skin
Note that this is not a full/complete list of the side effects of Esbriet.
If you experience severe or persistent adverse reactions, discontinue medication and call your doctor or any health care professional.
Warnings and Precautions
Do not take this prescription drug if you have a known allergy to pirfenidone or any inactive ingredients the capsule may contain. Always be watchful for any signs of serious allergic reactions, including trouble breathing, swelling of the face and neck, severe dizziness, swollen lymph nodes, hives/itchiness, and skin rashes. If this occurs, stop taking this oral medication and seek emergency medical help immediately.
This medication may be contraindicated for people with a history of kidney disease and liver disease. Also, due to possible drug interactions, you should discuss all the prescription medications, nonprescription medications, supplements, and herbal products you are taking.
Dizziness is a common adverse reaction to this medication. Practice safety caution when doing tasks that would need alertness, especially driving. You must also limit drinking alcohol while taking this tablet.
Pirfenidone can make you more sensitive to sun exposure. You should restrict or limit your time under the sun and avoid indoor tanning. When going outdoors, remember to apply sunblock lotion and wear protective clothing. If you notice skin blisters or get sunburned, tell your doctor immediately.
Pregnant and breastfeeding moms must take this oral drug only if extremely necessary. It is necessary to discuss all the possible risks with a healthcare provider.
Frequently Asked Questions (FAQs)
What is Esbriet used to treat?
IPF, or idiopathic pulmonary fibrosis, is treated with Esbriet (pirfenidone). This is a lung disease that causes shortness of breath, persistent cough, and loss of appetite.
Does Esbriet prolong life?
Yes, according to clinical trials, this medication can prolong life. It can increase the life expectancy by 2.47 years for patients with IPF.
Is Esbriet a steroid?
This oral medication is not a steroid or a corticosteroid. It belongs to the classification of drugs called pyridones.
Which is better, Ofev or Esbriet?
Ofev vs Esbriet – Both medications are used to treat idiopathic pulmonary fibrosis. As for Ofev, it is also used for chronic fibrosing interstitial lung diseases and systemic sclerosis-associated interstitial lung disease.
Is Esbriet an immunosuppressant?
This oral drug can affect the immune system. It weakens the body’s defense system while reducing lung scars.
Is Esbriet over the counter?
This product is a prescription medication for diabetes. You need to present a valid prescription when purchasing this product from any pharmacy.
How much does Esbriet cost?
Click here to check the list of prices on this page. To get the best deals, purchase it from a Pharma passport.