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Parnate 
Description
Generic Name: tranylcypromine
Drug Class: monoamine oxidase inhibitor (MAOI)
Indications
Parnate is an oral prescription drug used to treat major depressive disorder (MDD) among patients who have not responded satisfactorily to other antidepressants. This should not be used as an initial treatment for MDD due to the possible serious adverse reactions, drug interactions, and the need for dietary restrictions.
Dosage Forms
This is available in the form of a Parnate 10 mg tablet.
Parnate Mechanism of Action
The exact mechanism of this MAOI is not fully known. However, it is thought to potentiate the monoamine neurotransmitter activity right in the central nervous system or CNS. This results in the irreversible inhibition of the monoamine oxidase enzyme.
How to Take Parnate
Before starting to take Parnate, it is necessary to read the information leaflet or medication guide given by a healthcare professional. You must not take any medication unless you have understood the uses and directions. Further medical advice or information can be obtained from your doctor or pharmacist.
This tablet is only meant to be taken by mouth. This is usually prescribed in divided doses. It is suitable for consumption with or without meals. If you experience nausea, take it with a meal. After swallowing the tablet, drink plenty of water. If you need to split the tablet, ask for supervision from a healthcare provider.
Make a dosing schedule. Do not increase or decrease your Parnate dosage. Your physician may start with a low dose and gradually increase your dose to prevent adverse reactions. You should not take this oral drug more frequently than advised. Also, do not discontinue taking it abruptly to avoid Parnate withdrawal symptoms.
Parnate Side Effects
Mild & Common Side Effects:
-Dizziness
-Lightheadedness
-Headache
-Drowsiness
-Weakness
-Tiredness
-Trouble sleeping
-Dry mouth
-Constipation
Severe Side Effects:
-Fainting
-Shivering
-Swelling of the lower extremities
-Unusual weight gain
-Eye pain
-Vision changes
-Severe abdominal pain
-Persistent nausea and vomiting
-Yellowish eyes and skin
-Seizures
-Hypertensive crisis
-Serotonin syndrome
-Mental or mood changes
Note that this is not a full/complete list of the side effects of Parnate.
If you experience severe or persistent adverse reactions, discontinue medication and talk to your doctor or any health care professional.
Warnings and Precautions
Do not take this prescription drug if you have a known allergy to tranylcypromine or any inactive ingredients it may contain. You should always be aware of signs of serious allergic reactions, such as trouble breathing, swelling in your face and neck, severe dizziness, swollen lymph nodes, and hives/itchiness. Stop using this oral medication and seek emergency medical treatment right away if this happens.
This medication may be contraindicated for people with a history of stroke, high blood pressure, heart problems, pheochromocytoma, frequent headaches or migraine, liver disease, kidney disease, hyperthyroidism, seizures, Parkinson’s disease, glaucoma, schizophrenia, and bipolar disorder. You should also discuss all of your prescription and nonprescription medications, vitamins, and herbal products with your doctor owing to the possibility of drug interactions.
Dizziness, drowsiness, and vision changes are among the side effects of this SNRI. You should practice safety caution when doing tasks that require clear vision and alertness, especially driving. Further, this medication can interact with alcohol and worsen your symptoms or adverse effects. It may also put you at risk for liver damage. Avoid drinking alcohol while on this treatment.
Patients with diabetes should watch out as this drug can lower the levels of blood sugar. You must notify your physician if you experience signs of hypoglycemia, such as a fast heartbeat, shaking, sweating, tingling sensation, blurred vision, and dizziness.
Suicidal thoughts should be monitored in patients using this oral medication for major depressive disorder. Call your local suicide hotline once you observe sudden changes in behavior, altered sleeping patterns, social withdrawal, giving away important belongings, and lack of interest in pleasurable activities.
Pregnant women and lactating mothers must be informed of all the risks as soon as possible before taking this medication. This drug is known to pass into the breast milk.
What is the cost of Parnate?
You may see the list of prices on this page. To get the best deals, purchase your prescription drugs from PharmaPassport.
Frequently Asked Questions (FAQs)
What food should I avoid while taking Parnate?
Your Parnate diet should be centered on avoiding foods that are high in tyramine, including cheeses, caviar, sour cream, yeasts, soy sauce, yogurt, smoked or pickled products, and dried fruits. You should also avoid alcoholic drinks and those containing caffeine.
What are the long-term side effects of Parnate?
Some of the long-term effects of taking this MAOI are irritability, weakness, restlessness, and muscle twitches. It can be prevented by gradually reducing the dose according to your physician’s recommendation.
How long does it take Parnate to stop working?
Your appetite and energy may begin to improve within 1 to 2 weeks of regular use. It may take around 2 months for your condition to fully get better.
What is the difference between Parnate & Nardil?
Parnate vs Nardil – These drugs are both MAOI. However, they contain different active ingredients.
Can I use Parnate for social anxiety?
There are still no conclusive studies on Parnate & social anxiety. However, some physicians use it off-label to manage panic attacks.
Where can I get Parnate?
You may purchase this product from physical drugstores and online pharmacies. Please present a valid prescription when buying this medication.