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Premarin 
Description
Generic Name: conjugated estrogen
Drug Class: estrogen derivative
Premarin Details
Premarin is an oral prescription drug used to treat moderate to severe symptoms of vulvar and vaginal atrophy. It is also indicated to treat moderate to severe vasomotor symptoms, like hot flashes. Additionally, this is also used to treat other conditions like hypoestrogenism, breast cancer, and advanced androgen-dependent carcinoma of the prostate. It is also prescribed to prevent postmenopausal osteoporosis.
Have Side Effects of Premarin
Mild & Common Side Effects:
-Headache
-Nausea and vomiting
-Bloating
-Stomach upset
-Breast tenderness
-Weight changes
Severe Side Effects:
-Increased vaginal irritation
-Unusual vaginal bleeding
-Severe abdominal pain
-Persistent nausea and vomiting
-Swelling of the extremities
-Breast lumps
-Chest pain
-Unusual sweating
-Severe headache
-weakness on one side of the body
-Vision changes
-Sudden dizziness
-Confusion
-Mental or mood changes
Note that this is not a full/complete list of the side effects of Premarin.
If you experience severe or persistent adverse reactions, discontinue medication and call your doctor or health care professional.
Premarin Warnings
Do not take Premarin tablet if you have a known allergy to estradiol or any inactive ingredients the tablet may contain. Any indicators of major allergic reactions, such as problems breathing, swelling of the face and neck, severe dizziness, swollen lymph nodes, hives/itchiness, and skin rashes, should always be kept in mind. Stop using this oral medication and seek emergency medical treatment right away if this happens.
Premarin may be contraindicated for people with a history of breast cancer, ovarian cancer, cancer of the uterus, vaginal bleeding of unknown cause, blood clots, heart attack or any heart disease, kidney disease, liver disease, blood clotting disorders, angioedema, diabetes, high blood pressure, high levels of cholesterol and triglyceride, obesity, hypothyroidism, hypoparathyroidism, mineral imbalances, lupus, gallbladder disease, seizure, asthma, migraine, porphyria, uterus problems, any mental or mood disorders. You should also discuss all of your prescription and nonprescription medications, vitamins, and herbal products with your doctor owing to the possibility of drug interactions.
Estradiol can possibly increase the risk of blood clots. Tell your healthcare provider if you will be in a certain position for a long period, such as going through surgery or going on a long-haul flight. You may have to discontinue Premarin for a while under certain circumstances. Additionally, you should also avoid smoking or using tobacco, for they contain substances that can also increase the risk of blood clots.
This oral estradiol can also make you more sensitive to sun exposure. It can cause dark, blotchy patches on the face, called melasma. While using this drug, limit your exposure to the sun. You should also avoid indoor tanning and always wear protective clothing when going out.
This type of medication should not be used during pregnancy and while breastfeeding. It is essential to discuss all the possible risks with a healthcare provider.
Dosage Forms
This is available in Premarin 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, and 1.25 mg tablets.
Premarin Mechanism of Action
This works as the principal intracellular estrogen and is known to be more potent than estrone and estriol. It then regulates the pituitary secretion of follicle-stimulating hormones, luteinizing hormones, and gonadotropins via a negative feedback mechanism. It can also reduce the elevated levels of hormones among postmenopausal women.
How to Take Premarin
It is necessary to read the information leaflet or medication guide provided by a healthcare provider before beginning to use Premarin. You must not take Premarin unless you have read and comprehended the instructions and uses. For more medical advice or information, consult your doctor or pharmacist.
Premarin should only be consumed by mouth. This is usually prescribed once a day if taken for menopausal symptoms. It is suitable for consumption with or without meals. However, to reduce the risk of stomach discomfort or upset, you may take it with food. After swallowing the tablet, drink plenty of water.
Plan a dosing schedule. Do not increase or decrease your Premarin dosage. You should also not take this oral drug more frequently than advised.
Common Questions About Premarin
Who should not take Premarin?
Pregnant women must avoid Premarin. This is also contraindicated for those who have diabetes, hypertension, high cholesterol, and are overweight.
Are Estrace and Premarin the same thing?
Estrace vs Premarin – These medications are both available in oral and vaginal cream forms. While the former has estradiol, the latter contains conjugated estrogen.
Can Premarin be purchased over the counter?
This product is a prescription drug. You need to have a valid prescription before purchasing from any pharmacy.
What is The Price of Premarin?
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